Vpx complementation of ‘non-macrophage tropic’ R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages
نویسندگان
چکیده
منابع مشابه
R5 Macrophage-Tropic HIV-1 in the Male Genital Tract.
The entry tropism of HIV-1 Env proteins from virus isolated from the blood and genital tract of five men with compartmentalized lineages was determined. The Env proteins isolated from the genital tract of subject C018 were macrophage-tropic proteins, while the remaining cloned env genes encoded R5 T cell-tropic proteins. The detection of a macrophage-tropic lineage of HIV-1 within the male geni...
متن کاملWhere are macrophage-tropic viruses?
Results We examined virus in blood and CSF in eight subjects with advanced HIV disease and with neurocognitive involvement. All eight subjects had highly compartmentalized virus in comparing blood and CSF. In half of the subjects, the virus decayed rapidly in blood and CSF when therapy was initiated, and all env genes tested could infect cells only when there were high levels of CD4, both featu...
متن کاملViral Determinants of HIV-1 Macrophage Tropism
Macrophages are important target cells for HIV-1 infection that play significant roles in the maintenance of viral reservoirs and other aspects of pathogenesis. Understanding the determinants of HIV-1 tropism for macrophages will inform HIV-1 control and eradication strategies. Tropism for macrophages is both qualitative (infection or not) and quantitative (replication capacity). For example ma...
متن کاملEfficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.
HIV-1 R5 viruses vary extensively in their capacity to infect macrophages. R5 viruses that confer efficient infection of macrophages are able to exploit low levels of CD4 for infection and predominate in brain tissue, where macrophages are a major target for infection. HIV-1 R5 founder viruses that are transmitted were reported to be non-macrophage-tropic. Here, we investigated the sensitivitie...
متن کاملVisualization of X4- and R5-Tropic HIV-1 Viruses Expressing Fluorescent Proteins in Human Endometrial Cells: Application to Tropism Study
Worldwide most HIV infections occur through heterosexual transmission, involving complex interactions of cell-free and cell-associated particles with cells of the female genital tract mucosa. The ability of HIV-1 to "infect" epithelial cells remains poorly understood. To address this question, replicative-competent chimeric constructs expressing fluorescent proteins and harboring the envelope o...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2014
ISSN: 1742-4690
DOI: 10.1186/1742-4690-11-25